sparsentan will minimize the extent or effect of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Use Warning/Check. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and reduces efficacy relevant to these substrates.Effect of coadministration of a twin CYP3A4 and CYP2C19 inhibitor with fedratinib hasn't been studie
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